Lycorine Hydrochloride
Lycorine hydrochloride yog cov hmoov dawb mus rau dawb dawb ntawm cov alkaloid lycorine, uas muaj nyob rau hauv cov nroj tsuag ntawm Lycoris radiata (L'Her.), thiab belongs rau tsev neeg Amaryllidaceae. Lycorine hydrochloride muaj ntau yam tshuaj muaj peev xwm, suav nrog tshuaj tiv thaiv qog, tiv thaiv qog noj ntshav, tiv thaiv HCV, tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv angiogenesis, thiab tiv thaiv kab mob npaws. Nws yog soluble hauv dej, DMSO, thiab ethanol. Nws cov qauv tshuaj yog tus cwj pwm los ntawm cov txheej txheem steroidal nyuaj nrog lub iab saj nrog ntau pab pawg ua haujlwm, suav nrog hydroxyl thiab amino pawg, pab txhawb rau nws cov haujlwm lom neeg.
| Khoom npe | Lycorine Hydrochloride CAS: 2188-68-3 | ||
| Nroj tsuag | Lycoris | ||
| Kev cia khoom | Khaws nrog lub foob ntawm chav tsev kub | Tshaj tawm hnub | 2024.0 Nws8.24 |
| Yam khoom | Txuj | Kev tshwm sim |
| Purity(HPLC) | Lycorine hydrochloride≥98% | 99.7% |
| Qhov tshwm sim | Off-dawb hmoov | Ua raws |
| Tus cwj pwm ntawm lub cevcov ics | ||
| Particle-loj | NLT100% 80Mesh | Ua raws |
| Poob rau ziab | ≤ 1.0% | 1.8% |
| Hnyav hlau | ||
| Tag nrho cov hlau | ≤ 10.0ppm | Ua raws |
| Coj | ≤ 2.0ppm | Ua raws |
| Mercury | ≤ 1.0ppm | Ua raws |
| Cadmium | ≤0.5ppm | Ua raws |
| Kab mob | ||
| Tag nrho cov kab mob | ≤1000cfu / g | Ua raws |
| Poov xab | ≤100cfu / g | Ua raws |
| Escherichia coli | Tsis suav nrog | Tsis pom |
| Salmonella | Tsis suav nrog | Tsis pom |
| Staphylococcus | Tsis suav nrog | Tsis pom |
| Cov lus xaus | Tsim nyog | |
Nta:
(1) High Purity:Peb cov khoom tau ua tiav ua tiav los xyuas kom muaj qib siab purity, uas yog qhov tseem ceeb rau nws cov txiaj ntsig thiab kev nyab xeeb hauv ntau daim ntawv thov.
(2) Anticancer Properties:Nws tau pom tias muaj kev tiv thaiv kab mob loj heev rau ntau hom mob qog noj ntshav, ob qho tib si hauv vitro thiab hauv vivo, los ntawm cov txheej txheem xws li inducing cell voj voog ntes, ua rau apoptosis, thiab inhibiting angiogenesis.
(3) Multitargeted Action:Lycorine hydrochloride ntseeg tau tias muaj kev cuam tshuam nrog ntau lub hom phiaj molecular, muab kev ua haujlwm dav dav rau cov qog nqaij hlav cancer.
(4) Tsawg toxicity:Nws nthuav tawm cov tshuaj toxicity tsawg rau cov hlwb ib txwm, uas yog qhov tseem ceeb hauv nws txoj kev siv los ua tus neeg sawv cev kho.
(5) Pharmacokinetic Profile:Cov khoom lag luam tau kawm txog nws cov tshuaj pharmacokinetics, qhia txog kev nqus sai thiab tshem tawm cov ntshav sai sai, uas yog qhov tseem ceeb rau kev noj tshuaj thiab kev npaj kho mob.
(6) Synergistic Effects:Lycorine hydrochloride tau pom tias muaj txiaj ntsig zoo thaum siv nrog lwm cov tshuaj, uas tuaj yeem ua tau zoo hauv kev kov yeej cov tshuaj tiv thaiv thiab txhim kho cov txiaj ntsig kev kho mob.
(7) Kev Tshawb Fawb Rov Qab:Cov khoom lag luam tau txais kev txhawb nqa los ntawm kev tshawb fawb dav dav, muab lub hauv paus ruaj khov rau nws siv hauv kev tsim kho tshuaj thiab kev siv tshuaj kho mob.
(8) Quality Assurance:Kev tswj xyuas nruj nruj yog nyob rau hauv qhov chaw thoob plaws hauv cov txheej txheem tsim khoom kom ntseeg tau qhov sib xws thiab kev ntseeg siab ntawm cov khoom.
(9) Kev siv ntau yam:Tsim nyog siv rau hauv kev tshawb fawb thiab kev tsim kho rau kev siv tshuaj, suav nrog kev tshawb nrhiav tshuaj thiab kev kho mob qog noj ntshav.
(10) Ua raws li:Ua raws li GMP cov qauv los xyuas kom meej cov khoom muaj kev nyab xeeb thiab ua tau zoo.
(1) Pharmaceutical kev lag luam:Lycorine hydrochloride yog siv rau hauv kev tsim cov tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob.
(2) Biotechnology kev lag luam:Nws yog siv nyob rau hauv kev tshawb fawb thiab kev loj hlob ntawm cov tshiab kho cov neeg sawv cev thiab tshuaj formulations.
(3) Kev tshawb fawb cov khoom ntuj:Lycorine hydrochloride tau kawm txog nws cov txiaj ntsig kev noj qab haus huv thiab cov khoom siv tshuaj.
(4) Kev lag luam tshuaj:Nws tuaj yeem siv los ua cov tshuaj nruab nrab hauv kev sib txuas ntawm lwm cov tebchaw.
(5) Kev lag luam Agricultural:Lycorine hydrochloride tau raug tshawb xyuas rau nws lub peev xwm ua tshuaj tua kab thiab cog kev loj hlob regulator.
Cov txheej txheem rho tawm ntawm lycorine hydrochloride feem ntau suav nrog cov kauj ruam tseem ceeb hauv qab no los xyuas kom meej qhov purity ntawm cov kuab tshuaj thiab txhim kho tus nqi rov qab:
(1) Raw khoom xaiv thiab pretreatment:Xaiv qhov tsim nyog Amaryllidaceae cog raw cov ntaub ntawv, xws li Amaryllis qhov muag teev, thiab ntxuav, qhuav thiab zom lawv kom huv si ntawm cov ntaub ntawv raw thiab nteg lub hauv paus rau tom ntej extraction.
(2)Composite enzyme pretreatment:Siv cov enzymes nyuaj (xws li cellulase thiab pectinase) los ua ntej cov khoom siv crushed kom decompose cog cell phab ntsa thiab txhim kho cov kev ua haujlwm tom ntej.
(3)Dilute hydrochloric acid leaching:Sib tov cov khoom ua ntej pretreated nrog dilute hydrochloric acid tov kom rho tawm lycorine. Kev siv cov hydrochloric acid pab ua kom cov solubility ntawm lycorine, yog li txhim kho kev ua haujlwm ntawm cov extraction.
(4)Ultrasonic-pab extraction:Kev siv cov cuab yeej siv ultrasonic-pab extraction tuaj yeem ua kom cov txheej txheem tawg ntawm lycorine hauv cov kuab tshuaj thiab txhim kho kev ua haujlwm zoo thiab purity.
(5)Chloroform extraction:Kev rho tawm yog ua nrog cov kuab tshuaj organic xws li chloroform, thiab cov lycorine raug xa mus los ntawm cov theem aqueous mus rau theem organic ntxiv kom huv si lub hom phiaj.
(6)Solvent rov qab:Tom qab cov txheej txheem rho tawm, cov kuab tshuaj tau rov qab los ntawm evaporation lossis distillation kom txo tau cov kuab tshuaj thiab txhim kho kev lag luam.
(7)Purification thiab ziab:Los ntawm kev ua kom huv thiab ziab kom zoo, cov hmoov ntshiab lycorine hydrochloride tau txais.
Thoob plaws hauv tag nrho cov txheej txheem rho tawm, tswj kev xaiv cov kuab tshuaj, cov txheej txheem rho tawm (xws li pH tus nqi, kub, thiab lub sijhawm), thiab cov kauj ruam tom ntej purification yog tus yuam sij kom ntseeg tau cov kuab tshuaj purity thiab txhim kho tus nqi rov qab. Kev siv cov khoom siv niaj hnub rho tawm thiab purification, xws li ultrasonic extractors thiab high-performance kua chromatography (HPLC) systems, kuj pab txhim kho extraction efficiency thiab cov khoom zoo.
Cia: Khaws nyob rau hauv qhov chaw txias, qhuav, thiab huv si, tiv thaiv los ntawm noo noo thiab ncaj qha teeb.
Ntim Pob: 25kg / nruas.
Lub Sijhawm Lead: 7 hnub tom qab koj xaj.
Lub neej txee: 2 xyoos.
Lus Cim: Customized specifications kuj tuaj yeem ua tiav.
Qhia
Hauv 100kg, 3-5 Hnub
Qhov rooj rau qhov rooj kev pabcuam yooj yim tuaj tos cov khoom
Los ntawm Hiav Txwv
Tshaj 300kg, Nyob ib ncig ntawm 30 Hnub
Chaw nres nkoj rau chaw nres nkoj kev pab cuam clearance broker xav tau
Los ntawm Cua
100kg-1000kg, 5-7days
Tshav dav hlau mus rau tshav dav hlau kev pab cuam clearance broker xav tau
Bioway Organic tau txais USDA thiab EU organic, BRC, ISO, HALAL, KOSHER, thiab HACCP daim ntawv pov thawj.
Lycorine yog ib txwm tshwm sim alkaloid uas tuaj yeem pom hauv ntau cov nroj tsuag, tshwj xeeb hauv tsev neeg Amaryllidaceae. Nov yog qee cov nroj tsuag paub tias muaj lycorine:
Lycoris radiata(tseem hu ua kab laug sab liab liab lossis manjushage) yog cov tshuaj suav tshuaj suav tshuaj uas muaj lycorine.
Leucojum aestivum(lub caij ntuj sov snowflake), kuj paub tias muaj lycorine.
Ungernia sewertzowiiyog lwm tsob nroj los ntawm tsev neeg Amaryllidaceae uas tau tshaj tawm tias muaj lycorine.
Hippeastrum hybrid (Lub Easter Lily)thiab lwm yam nroj tsuag Amaryllidaceae yog paub qhov chaw ntawm lycorine.
Cov nroj tsuag no tau nthuav dav hauv thaj chaw sov thiab subtropical thoob plaws ntiaj teb thiab muaj keeb kwm ntev ntawm kev siv tshuaj ib txwm siv. Lub xub ntiag ntawm lycorine nyob rau hauv cov nroj tsuag no tau raug kev tshawb fawb vim nws muaj peev xwm pharmacological zog, nrog rau nws cov tseem ceeb anticancer teebmeem raws li pom nyob rau hauv ntau yam kev tshawb fawb.
Lycorine yog lub ntuj alkaloid uas muaj ntau yam tshuaj muaj txiaj ntsig, suav nrog nws cov peev xwm siv hauv kev kho mob qog noj ntshav. Thaum nws tau pom cov txiaj ntsig tau zoo hauv ntau qhov kev tshawb fawb, muaj qee qhov qhia txog kev mob tshwm sim thiab kev txiav txim siab cuam tshuam nrog nws siv:
Tsawg Toxicity: Lycorine thiab nws cov ntsev hydrochloride feem ntau pom muaj toxicity tsawg, uas yog cov yam ntxwv zoo rau kev siv tshuaj kho mob. Nws tau pom tias muaj qhov cuam tshuam tsawg kawg nkaus rau tib neeg lub cev thiab cov nas noj qab haus huv, qhia txog qee theem ntawm kev xaiv rau cov qog nqaij hlav cancer dua li cov ntaub so ntswg.
Transient Emetic Effects: Kev xeev siab thiab ntuav tau pom tom qab txhaj tshuaj subcutaneous lossis intravenously ntawm lycorine hydrochloride, feem ntau txo qis hauv 2.5 teev yam tsis muaj kev cuam tshuam rau biochemical lossis hematological kev nyab xeeb.
Tsis muaj kev sib koom ua ke ntawm lub cev muaj zog: Cov kev tshawb fawb tau pom tias cov koob tshuaj ntawm lycorine tsis cuam tshuam rau kev sib koom ua ke ntawm lub cev muaj zog hauv cov nas, raws li kev sim rotarod test, qhia tias nws tsis ua rau lub hauv paus paj hlwb (CNS) cuam tshuam txog kev tswj lub cev muaj zog.
Kev cuam tshuam rau kev ua haujlwm ntawm tus kheej Locomotor: Ntawm koob tshuaj 30 mg / kg, lycorine tau pom tias ua rau muaj kev cuam tshuam rau kev ua haujlwm ntawm locomotor hauv nas, raws li qhia los ntawm kev txo qis hauv kev coj tus cwj pwm thiab nce hauv immobility.
Kev Coj Tus Cwj Pwm thiab Kev Noj Qab Haus Huv: Ib koob tshuaj 10 mg / kg ntawm lycorine tsis cuam tshuam rau kev coj tus cwj pwm thiab kev noj qab haus huv ntawm cov nas, qhia tias qhov no tuaj yeem yog qhov koob tshuaj zoo tshaj plaws rau kev ntsuas kev kho mob yav tom ntej.
Tsis muaj qhov cuam tshuam loj heev rau lub cev qhov hnyav lossis kev noj qab haus huv: Kev tswj hwm ntawm lycorine thiab lycorine hydrochloride tsis ua rau muaj kev phiv tshwm sim ntawm lub cev qhov hnyav lossis tag nrho kev noj qab haus huv hauv cov qog nqaij hlav nas.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias thaum lycorine tau pom muaj peev xwm hauv kev tshawb xyuas ua ntej, kev ntsuas tshuaj lom mus ntev tseem tsis muaj. Kev tshawb fawb ntxiv yog xav tau kom nkag siab tag nrho nws cov ntaub ntawv kev nyab xeeb, tshwj xeeb tshaj yog rau kev siv mus ntev thiab hauv chaw kho mob. Cov kev mob tshwm sim thiab kev nyab xeeb ntawm lycorine yuav txawv nyob ntawm qhov ntau npaum li cas, txoj kev tswj hwm, thiab tus yam ntxwv ntawm tus neeg mob. Nco ntsoov sab laj nrog tus kws kho mob ua ntej txiav txim siab siv cov tshuaj ntxiv lossis kev kho mob tshiab.
