Lycorine hydrochloride
Lycorine hydrochloride yog ib qho dawb kom tawm-dawb hmoov derivative ntawm alkaloid laseas, uas yog pom nyob rau hauv cov nroj tsuag ntawm Lycoris radiata (l Lycorine hydrochloride has various potential pharmacological effects, including anti-tumor, anti-cancer, anti-HCV, anti-inflammatory, anti-bacterial, anti-virus, anti-angiogenesis, and anti-malaria properties. Nws yog soluble hauv dej, DMOPS, thiab Ethanol. Nws cov qauv tshuaj yog tus cwj pwm los ntawm cov txheej txheem sterexal nrog cov pawg iab nrog ntau pawg, suav nrog cov pab pawg hydroxyl thiab amino.
| Khoom npe | Lycorine Cas: 2188-68-3 | ||
| Tsob Nroj Chaw | Las voos | ||
| Chaw Cia Khoom | Khw nrog daim foob ntawm chav tsev kub | Daim Ntawv Qhia Hnub | 2024.08Cov .24 |
| Yam | Lub hom phiaj | Qho kawg |
| Kev coj dawb huv(HPLC) | Lycorine hydrochloride≥96% | 99.7% |
| Kev tshwm sim | Tawm-dawb hmoov | Ntuas |
| Lub Cev Cwj Pwmdaim ics | ||
| Particle-loj | Nlt100% 80Ntxaij | Ntuas |
| Poob rau ziab | ≤1.0% | 1.8% |
| Hnyav hlau | ||
| Tag nrho cov hlau | ≤10.0ppm | Ntuas |
| Hlau | ≤2.0ppm | Ntuas |
| Quavriculy | I≤1.0PPM | Ntuas |
| Tus cadmium | I≤0.5ppm | Ntuas |
| Kablab | ||
| Tag nrho cov kab mob | ≤1000CFU / G | Ntuas |
| Poov xab | ≤100CFU / G | Ntuas |
| Escherichia coli | Tsis suav nrog | Tsis pom |
| Tus ntses siav | Tsis suav nrog | Tsis pom |
| Staphylococcus | Tsis suav nrog | Tsis pom |
| Cov lus xaus | Muaj cai | |
Nta:
(1) Siab Purity:Peb cov khoom yog qhov ua tau zoo me ntsis ua kom muaj kev coj dawb huv, uas yog qhov tseem ceeb rau nws cov hauj lwm zoo thiab kev nyab xeeb hauv ntau yam kev siv.
(2) anticancer muaj zog:Nws tau pom tias muaj txiaj ntsig anticancer cuam tshuam rau ntau hom kev mob cancer, ntawm kev ua kom muaj kev cuam tshuam nrog kev ua haujlwm celling, los ntawm kev ua yeeb yam ntawm lub voj voog ntawm lub voj voog, ua rau mob siab, thiab inhibiting angiogenesis.
(3) kev txiav txim siab multiTargeted:Lycorine hydrochloride yog ntseeg tau los cuam tshuam nrog ntau lub hom phiaj molecular, muab cov txiaj ntsig dav dav rau cov qog nqaij hlav cancer.
(4) muaj txiaj ntsig tsawg:Nws nthuav tawm cov tshuaj lom tsawg rau cov hlwb ib txwm muaj, uas yog qhov tseem ceeb hauv nws cov peev xwm siv los ua tus saib xyuas kev kho mob.
(5) Cov Khoom Siv Hluav Taws Xob:Cov khoom tau kawm tau kawm rau nws cov tshuaj papacokass, qhia kev nqus cov nrawm thiab tshem tawm sai sai los ntawm cov ntshav, uas yog qhov tseem ceeb rau kev npaj siv tshuaj thiab kev kho mob.
(6) cov teebmeem kev cuam tshuam:Lycorine hydrochloride tau qhia kev txhim kho txhim kho thaum siv ua ke nrog lwm cov tshuaj, uas tuaj yeem muaj txiaj ntsig zoo rau cov yeeb tshuaj tiv thaiv tshuaj thiab txhim kho cov txiaj ntsig kev kho mob.
(7) Kev Tshawb Nrhiav-thaub qab:Cov khoom yog txhawb los ntawm cov kev tshawb fawb dav dav, muab lub hauv paus ruaj khov rau nws siv hauv kev siv tshuaj kho mob.
(8) Kev lees paub zoo:Kev ntsuas nruj kev tswj hwm zoo yog nyob rau hauv thoob plaws cov txheej txheem ntau lawm los xyuas kom meej thiab ntseeg tau ntawm cov khoom.
(9) Ntau cov ntawv thov:Haum rau kev siv hauv kev tshawb fawb thiab kev txhim kho cov ntaub ntawv thov tshuaj, suav nrog kev paub tshuaj thiab kev kho mob cancer.
(10) Ua raws li:Tsim cov qauv GMP kom ntseeg tau tias cov khoom muaj kev nyab xeeb thiab ua tau zoo.
(1) kev lag luam kws tshuaj:Lycorine hydrochloride yog siv nyob rau hauv kev txhim kho cov tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob anticancer.
(2) Kev Lag Luam Biotechnology:Nws tau siv hauv kev tshawb fawb thiab kev txhim kho kev kho tshiab kho cov neeg sawv cev thiab tshuaj ua qauv.
(3) Kev Tshawb Fawb Cov Khoom Lag Luam:Lycorine hydrochloride yog kawm rau nws cov txiaj ntsig kev noj qab haus huv thiab muaj nyiaj txiag.
(4) Kev Lag Luam Tshuaj:Tej zaum nws yuav raug siv los ua tshuaj lom neeg hauv nruab nrab hauv kev sib txuas ntawm lwm cov tebchaw.
(5) Kev lag luam kev lag luam:Lycorine hydrochloride tau raug tshuaj xyuas rau nws lub peev xwm ua lub ntuj kev tswj hwm thiab cog ntoo kev loj hlob.
Cov txheej txheem rho tawm ntawm Lycorine hydrochloride feem ntau suav nrog cov kauj ruam tseem ceeb hauv qab no kom ntseeg tau tias cov kuab tshuaj thiab txhim kho tus nqi rov qab:
(1) Cov khoom siv raw thiab pretreatment:Xaiv cov amaryllidaceae cog raw cov ntaub ntawv, thiab ua kom qhuav, qhuav thiab tsoo lawv kom ntseeg tau tias cov ntaub ntawv raw thiab nteg lub hauv paus rau kev rho tawm tom ntej.
(2)Composite enzyme pretreatment:Siv cov enzymes complex (xws li cellulase thiab pectinase) los ua kom cov khoom siv raw rau cov khoom siv xov tooj ntawm tes thiab txhim kho cov khoom siv tau ua haujlwm ntawm tes thiab txhim kho cov khoom siv hauv tes thiab txhim kho cov extraction tom ntej.
(3)Dilute Dilute Hydrochloric Acid Leaching:Sib tov pretrasted raw cov ntaub ntawv nrog dilute hydrochloric acid inluts mus rau extract siycorine. Kev siv ntawm hydrochloric acid pab kom nce cov solubility ntawm lasycorine, yog li kev txhim kho cov kev ua tau zoo.
(4)Ultrasonic-pab tau Extraction:Kev siv ntawm ultrasonic-pab txhawb kev thev naus laus zis tuaj yeem ua kom nrawm dua kev sib cais ntawm cov qib siab thiab txhim kho cov tshuaj tiv thaiv thiab kev ua kom huv.
(5)Chloroform Extraction:Extraction tau ua nrog cov kuab tshuaj organic xws li chloroform, thiab lub lasorine pauv los ntawm theem aqueous mus rau cov organic theem ntxiv rau kev ua kom dawb huv lub hom phiaj.
(6)Hnyav rov qab:Tom qab cov txheej txheem rho tawm, cov lus qhia tau zoo los ntawm evaporation lossis distillation kom txo cov kuab tshuaj thiab txhim kho kev lag luam.
(7)Purification thiab ziab:Los ntawm cov kauj ruam tsim nyog thiab ua kom qhuav, kom huv lycordine hydrochloride hmoov tau txais.
Thoob plaws tag nrho cov txheej txheem extraction, tswj cov kev xaiv ntawm cov kuab tshuaj, thiab sijhawm ua kom huv si yog qhov tseem ceeb los txhim kho kev coj dawb huv thiab kev txhim kho tus nqi rov qab. Kev siv cov khoom niaj hnub niaj hnub thiab cov khoom siv ua kom zoo nkauj, xws li ultrasonic extractors thiab qib siab ua kua chromatography (HPLC), kuj tseem pab txhim kho kev ua kom muaj zog thiab cov khoom zoo.
Cia: Cia rau hauv qhov chaw txias, qhuav, thiab huv si, tiv thaiv los ntawm ya raws thiab lub teeb ncaj qha.
Bulk pob: 25kg / nruas.
Lub Sijhawm Lead: 7 hnub tom qab koj xaj.
Txee lub neej: 2 xyoos.
Cim: Cov lus qhia tshwj xeeb kuj tuaj yeem ua tiav.
Ua
Nyob rau hauv 100kg, 3-5days
Qhov rooj mus rau qhov chaw pab yooj yim tos cov khoom
Los ntawm hiav txwv
Tshaj300kg, ncig 30 hnub
Chaw nres nkoj mus rau Chaw Pabcuam Chaw Haujlwm Caj Vev Chaw
Los ntawm huab cua
100kg-1000Kg, 5-7days
Tshav dav hlau rau tshav dav hlau kev pab cuam condance broker xav tau
Bioway Organic tau txais USDA thiab EU organic, Brc, ISO, HALAL, KOSHER, thiab HACCP cov ntawv pov thawj.
Lycorine yog ib qho tshwm sim alkaloid uas tuaj yeem nrhiav tau hauv ob peb cov nroj tsuag, tshwj xeeb tshaj yog nyob hauv cov amaryllitaceae tsev neeg. Nov yog qee cov nroj tsuag paub tias muaj Lycorine:
Lycoris radiata(Kuj tseem hu ua tus kab laug sab sib tw Lily lossis MANJushage) yog ib txwm tshuaj tshuaj ntsuab tshuaj ntsuab uas muaj Lycorine.
Leucojum Aestivum(Lub caij ntuj sov snowlake), yog tseem paub tias muaj lasycordine.
Ungernia seftzowiiPuas yog lwm tsob ntoo los ntawm Amaryllidaceae tsev neeg uas tau tshaj tawm tias muaj Lycorine.
Hippeastrum hybrid (Easter Lily)Thiab lwm yam amaryllidaceae nroj tsuag yog paub txog cov khoom ntawm kev ua si.
Cov nroj tsuag no tau faib dav hauv thaj chaw kub thiab muaj huab cua nyob thoob ntiaj teb thiab muaj keeb kwm ntev los ntawm kev siv tshuaj ib txwm muaj tshuaj. Lub xub ntiag ntawm cov roj hauv cov nroj tsuag tau yog qhov kev tshawb fawb vim nws cov peev xwm muaj peev xwm, suav nrog nws cov kev tshawb fawb tseem ceeb uas pom hauv ntau txoj kev kawm.
Lycorine yog ntuj alkaloid nrog ntau yam ntawm cov tshuaj pharmacological cuam tshuam, suav nrog kev kho mob cancer. Thaum nws tau qhia cov lus cog tseg hauv ntau txoj kev tshawb fawb, muaj qee cov kev tshwm sim thiab kev txiav txim siab cuam tshuam nrog nws siv:
Tsawg toxicity: lasycorine thiab nws cov ntsev hydrochloride feem ntau nthuav tawm cov kev ntsuas mob tsawg, uas yog cov txiaj ntsig zoo rau cov ntawv thov kev kho mob. Nws tau pom tias muaj kev cuam tshuam tsawg kawg ntawm tib neeg cov hlwb thiab cov nas noj qab haus huv, qhia txog qee theem ntawm kev xaiv cov qog nqaij hlav cancer dhau cov ntaub so ntswg.
Kev cuam tshuam Emetic los: Chanient fullschloride, feem ntau yog kev sib koom ua ke tsis muaj kev cuam tshuam kev nyab xeeb lossis hematological.
Tsis muaj qhov tsis zoo lub cev muaj zog lub cev muaj zog: kev tshawb fawb tau qhia tias cov tshuaj ntsuas lub tsheb, qhia tias nws tsis ua rau lub cev muaj zog (CNS) cov kev mob tshwm sim ntsig txog kev tswj hwm lub cev muaj zog.
Kev cuam tshuam rau ntawm kab ke ntawm kev ua si: ntawm qhov koob tshuaj ntawm 30 mg / kg, lascorine tau pom rau qhov tsis txaus ntseeg hauv nas
Kev coj cwj pwm dav dav thiab kev ua haujlwm zoo: ib koob tshuaj ntawm Lycorine tsis kam lees paub txog kev tshuaj xyuas kev ua tau zoo.
Tsis muaj cov kev cuam tshuam zoo rau lub cev nyhav lossis kev coj noj qab haus huv: tswj hwm hydrochloride tsis ua rau pom cov kev mob hauv lub cev lossis cov qauv kev noj qab haus huv tag nrho hauv cov qog nas.
Nws yog ib qho tseem ceeb kom nco ntsoov tias thaum lub sijhawm Lycorine tau pom muaj peev xwm ua cov tshuaj ntsuam xyuas, kev ntsuas ntev ntev yog tseem tsis txaus. Cov kev tshawb fawb ntxiv yog xav tau kom nkag siab txog nws cov ntaub ntawv muaj kev nyab xeeb, tshwj xeeb rau kev siv ntev thiab hauv chaw kho mob. Cov kev phiv thiab kev nyab xeeb ntawm kev ua si lasycorine yuav sib txawv raws li kev noj tshuaj, thiab cov qauv tswj hwm, thiab tus kheej tus yam ntxwv. Ib txwm sab laj nrog tus kws tshaj lij kev noj qab haus huv ua ntej kev txiav txim siab siv txhua yam tshiab ntxiv lossis kev kho mob.
