Lycorine Hydrochloride
Lycorine hydrochloride yog ib hom hmoov dawb mus rau dawb tawm ntawm cov alkaloid lycorine, uas pom muaj nyob rau hauv cov nroj tsuag ntawm Lycoris radiata (L'Her.), thiab yog cov nroj tsuag ntawm Amaryllidaceae. Lycorine hydrochloride muaj ntau yam kev cuam tshuam pharmacological, suav nrog kev tiv thaiv qog, tiv thaiv mob qog noj ntshav, tiv thaiv HCV, tiv thaiv kev o, tiv thaiv kab mob, tiv thaiv kab mob, tiv thaiv kab mob angiogenesis, thiab tiv thaiv kab mob malaria. Nws yaj tau hauv dej, DMSO, thiab ethanol. Nws cov qauv tshuaj lom neeg yog tus cwj pwm los ntawm cov qauv steroidal nyuaj nrog qhov saj iab nrog ntau pawg ua haujlwm, suav nrog hydroxyl thiab amino pawg, pab txhawb rau nws cov haujlwm biological.
| Lub npe khoom | Lycorine hydrochloride CAS: 2188-68-3 | ||
| Qhov Chaw Cog Qoob Loo | Lycoris | ||
| Kev khaws cia | Khaws cia nrog lub foob rau ntawm chav sov | Hnub qhia | 2024.08.24 |
| Khoom | Tus Qauv | Qhov tshwm sim |
| Kev dawb huv（HPLC) | Lycorine hydrochloride≥98% | 99.7% |
| Qhov tsos | Hmoov dawb tawm | Ua raws li |
| Tus cwj pwm lub cevics | ||
| Qhov loj ntawm cov khoom me me | NLT100% 80Mesh | Ua raws li |
| Poob thaum ziab | ≤1.0% | 1.8% |
| Hnyav hlau | ||
| Tag nrho cov hlau | ≤10.0ppm | Ua raws li |
| Cov hlau lead | ≤2.0ppm | Ua raws li |
| Mercury | ≤1.0ppm | Ua raws li |
| Cadmium | ≤0.5ppm | Ua raws li |
| Cov kab mob me me | ||
| Tag nrho cov kab mob | ≤1000cfu/g | Ua raws li |
| Cov poov xab | ≤100cfu/g | Ua raws li |
| Escherichia coli | Tsis suav nrog | Tsis tau pom |
| Salmonella | Tsis suav nrog | Tsis tau pom |
| Staphylococcus | Tsis suav nrog | Tsis tau pom |
| Cov Lus Xaus | Tsim nyog | |
Nta:
(1) Kev Ntshiab Siab:Peb cov khoom raug ua tiav zoo kom ntseeg tau tias muaj qib siab ntawm kev huv, uas yog qhov tseem ceeb rau nws txoj kev ua haujlwm zoo thiab kev nyab xeeb hauv ntau yam kev siv.
(2) Cov Khoom Siv Tiv Thaiv Kab Mob Cancer:Nws tau ua pov thawj tias muaj cov txiaj ntsig zoo ntawm kev tiv thaiv kab mob qog noj ntshav ntau yam kab mob qog noj ntshav, ob qho tib si hauv vitro thiab hauv vivo, los ntawm cov txheej txheem xws li kev ua kom lub voj voog ntawm lub hlwb tsis ua haujlwm, ua rau apoptosis, thiab inhibiting angiogenesis.
(3) Kev Ua Haujlwm Ntau Lub Hom Phiaj:Lycorine hydrochloride ntseeg tau tias cuam tshuam nrog ntau lub hom phiaj molecular, muab kev ua haujlwm dav dav tiv thaiv cov hlwb qog noj ntshav.
(4) Kev Lom Zem Tsawg:Nws qhia txog kev lom tsawg rau cov hlwb ib txwm muaj, uas yog ib qho tseem ceeb hauv nws txoj kev siv ua tus neeg sawv cev kho mob.
(5) Cov Ntaub Ntawv Txog Kev Siv Tshuaj:Cov khoom no tau raug kawm txog nws cov tshuaj pharmacokinetics, qhia txog kev nqus sai thiab kev tshem tawm sai ntawm cov ntshav, uas yog qhov tseem ceeb rau kev noj tshuaj thiab kev npaj kho mob.
(6) Cov teebmeem sib koom ua ke:Lycorine hydrochloride tau pom tias muaj txiaj ntsig zoo dua thaum siv ua ke nrog lwm cov tshuaj, uas tuaj yeem pab tau kom kov yeej kev tiv thaiv tshuaj thiab txhim kho cov txiaj ntsig kev kho mob.
(7) Kev Tshawb Fawb Txhawb Nqa:Cov khoom no tau txais kev txhawb nqa los ntawm kev tshawb fawb ntau yam, muab lub hauv paus ruaj khov rau nws siv rau hauv kev tsim tshuaj thiab kev siv hauv kev kho mob.
(8) Kev Ntsuam Xyuas Zoo:Muaj kev tswj xyuas zoo nruj thoob plaws hauv cov txheej txheem tsim khoom kom ntseeg tau tias cov khoom zoo sib xws thiab ntseeg tau.
(9) Cov Ntawv Thov Ntau Yam:Haum rau kev siv rau hauv kev tshawb fawb thiab kev txhim kho rau kev siv tshuaj, suav nrog kev tshawb pom tshuaj thiab kev tsim kho mob qog noj ntshav.
(10) Kev Ua Raws Cai:Ua raws li cov qauv GMP kom ntseeg tau tias cov khoom muaj kev nyab xeeb thiab ua haujlwm tau zoo.
(1) Kev lag luam tshuaj:Lycorine hydrochloride yog siv rau hauv kev tsim cov tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob qog noj ntshav.
(2) Kev lag luam biotechnology:Nws yog siv rau hauv kev tshawb fawb thiab kev tsim cov neeg sawv cev kho mob tshiab thiab cov qauv tshuaj.
(3) Kev tshawb fawb txog cov khoom ntuj tsim:Lycorine hydrochloride raug kawm txog nws cov txiaj ntsig kev noj qab haus huv thiab cov khoom siv kho mob.
(4) Kev lag luam tshuaj lom neeg:Nws yuav raug siv ua ib qho tshuaj intermediate hauv kev sib xyaw ntawm lwm cov tshuaj.
(5) Kev lag luam ua liaj ua teb:Lycorine hydrochloride tau raug tshawb nrhiav txog nws lub peev xwm ua ib yam tshuaj tua kab thiab tshuaj tswj kev loj hlob ntawm cov nroj tsuag.
Cov txheej txheem rho tawm ntawm lycorine hydrochloride feem ntau suav nrog cov kauj ruam tseem ceeb hauv qab no kom ntseeg tau tias qhov huv ntawm cov kuab tshuaj thiab txhim kho qhov rov qab los:
(1) Kev xaiv cov khoom siv raw thiab kev kho ua ntej:Xaiv cov khoom siv raw ntawm cov nroj tsuag Amaryllidaceae uas tsim nyog, xws li cov noob Amaryllis, thiab ntxuav, ziab thiab tsoo lawv kom ntseeg tau tias cov khoom siv raw huv thiab teeb tsa lub hauv paus rau kev rho tawm tom qab.
(2)Kev kho ua ntej ntawm cov enzyme sib xyaw ua ke:Siv cov enzymes nyuaj (xws li cellulase thiab pectinase) los kho cov khoom siv raw uas raug tsoo kom rhuav tshem cov phab ntsa cell ntawm cov nroj tsuag thiab txhim kho kev ua haujlwm tom qab.
(3)Kev siv cov tshuaj hydrochloric acid los ntxuav cov kua qaub:Sib tov cov khoom siv raw uas tau kho ua ntej nrog cov kua hydrochloric acid dilute kom rho tawm lycorine. Kev siv hydrochloric acid pab ua kom lycorine solubility ntau dua, yog li ua kom zoo dua qhov kev rho tawm.
(4)Kev rho tawm los ntawm kev pab los ntawm ultrasonic:Kev siv cov thev naus laus zis pab txhawb nqa ultrasonic tuaj yeem ua kom cov txheej txheem yaj ntawm lycorine hauv cov kuab tshuaj thiab txhim kho kev ua haujlwm rho tawm thiab kev huv.
(5)Kev rho tawm ntawm chloroform:Kev rho tawm yog ua tiav nrog cov organic solvents xws li chloroform, thiab lycorine raug hloov los ntawm theem aqueous mus rau theem organic kom ntxiv purify lub hom phiaj compound.
(6)Kev rov qab tau cov kuab tshuaj:Tom qab cov txheej txheem rho tawm, cov kuab tshuaj tau rov qab los ntawm kev ua kom qhuav lossis kev sib xyaw kom txo qis kev siv cov kuab tshuaj thiab txhim kho kev lag luam.
(7)Kev ntxuav thiab ziab:Los ntawm kev ntxuav thiab ziab kom huv, cov hmoov lycorine hydrochloride ntshiab tau txais.
Thoob plaws hauv tag nrho cov txheej txheem rho tawm, kev tswj hwm kev xaiv cov kuab tshuaj, cov xwm txheej rho tawm (xws li pH tus nqi, kub, thiab lub sijhawm), thiab cov kauj ruam ntxuav tom qab ntawd yog qhov tseem ceeb rau kev ua kom cov kuab tshuaj huv thiab txhim kho tus nqi rov qab. Kev siv cov khoom siv rho tawm thiab ntxuav niaj hnub, xws li cov tshuab rho tawm ultrasonic thiab cov tshuab ua kua chromatography (HPLC) ua haujlwm siab, kuj pab txhim kho kev ua haujlwm rho tawm thiab cov khoom zoo.
Kev Khaws Cia: Khaws cia rau qhov chaw txias, qhuav, thiab huv si, Tiv thaiv kom tsis txhob muaj dej noo thiab lub teeb ncaj qha.
Pob Khoom Loj: 25kg / nruas.
Lub Sijhawm Ua Ntej: 7 hnub tom qab koj xaj.
Lub Neej Txee: 2 xyoos.
Lus Cim: Cov lus qhia tshwj xeeb kuj tuaj yeem ua tiav.
Express
Hauv qab 100kg, 3-5 Hnub
Kev pabcuam qhov rooj mus rau qhov rooj yooj yim los khaws cov khoom
Los ntawm Hiav Txwv
Tshaj 300kg, Kwv yees li 30 Hnub
Xav tau tus neeg ua haujlwm tshaj lij kev tshem tawm chaw nres nkoj mus rau chaw nres nkoj
Los ntawm Huab Cua
100kg-1000kg, 5-7 Hnub
Xav tau tus neeg ua haujlwm tshaj lij txog kev tshem tawm cov kev pabcuam ntawm tshav dav hlau mus rau tshav dav hlau
Bioway Organic tau txais daim ntawv pov thawj USDA thiab EU organic, BRC, ISO, HALAL, KOSHER, thiab HACCP.
Lycorine yog ib qho alkaloid uas muaj nyob hauv ntau hom nroj tsuag, tshwj xeeb tshaj yog hauv tsev neeg Amaryllidaceae. Nov yog qee cov nroj tsuag uas paub tias muaj lycorine:
Lycoris radiata(tseem hu ua paj liab kab laug sab lossis manjushage) yog tshuaj ntsuab Suav uas muaj lycorine.
Leucojum aestivum(lub caij ntuj sov paj daus), kuj paub tias muaj lycorine.
Ungernia sewertzowiiyog lwm cov nroj tsuag los ntawm tsev neeg Amaryllidaceae uas tau tshaj tawm tias muaj lycorine.
Hippeastrum hybrid (Easter lily)thiab lwm yam nroj tsuag Amaryllidaceae yog cov chaw paub ntawm lycorine.
Cov nroj tsuag no muaj ntau nyob rau hauv thaj chaw sov thiab thaj chaw sov thoob plaws ntiaj teb thiab muaj keeb kwm ntev ntawm kev siv tshuaj kho mob ib txwm muaj. Qhov muaj lycorine nyob rau hauv cov nroj tsuag no tau yog lub ntsiab lus ntawm kev tshawb fawb vim nws cov khoom muaj peev xwm pharmacological, suav nrog nws cov teebmeem anticancer tseem ceeb raws li tau pom hauv ntau txoj kev tshawb fawb.
Lycorine yog ib qho alkaloid ntuj uas muaj ntau yam kev cuam tshuam pharmacological, suav nrog nws cov peev xwm siv rau hauv kev kho mob qog noj ntshav. Txawm hais tias nws tau pom cov txiaj ntsig zoo hauv ntau txoj kev tshawb fawb, muaj qee qhov kev tshaj tawm txog kev phiv thiab kev xav txog kev siv nws:
Kev Lom Zem Tsawg: Lycorine thiab nws cov ntsev hydrochloride feem ntau muaj kev lom zem tsawg, uas yog ib qho zoo rau kev siv hauv kev kho mob. Nws tau pom tias muaj cov teebmeem tsis zoo rau cov hlwb tib neeg thiab cov nas noj qab haus huv, qhia txog qee qib kev xaiv rau cov hlwb mob qog noj ntshav dua li cov ntaub so ntswg ib txwm muaj.
Cov Teeb Meem Ntawm Kev Ntshai Ib Ntus: Tau pom muaj kev xeev siab thiab ntuav ib ntus tom qab txhaj tshuaj lycorine hydrochloride rau hauv daim tawv nqaij lossis hauv cov hlab ntsha, feem ntau ploj mus hauv 2.5 teev yam tsis cuam tshuam rau kev nyab xeeb ntawm cov tshuaj biochemical lossis hematological.
Tsis Muaj Kev Sib Koom Tes Ua Haujlwm Tsis Zoo: Cov kev tshawb fawb tau qhia tias cov koob tshuaj lycorine tsis cuam tshuam rau kev sib koom tes ua haujlwm hauv nas, raws li tau sim los ntawm kev sim rotarod, qhia tias nws tsis ua rau muaj kev phiv los ntawm lub paj hlwb hauv nruab nrab (CNS) ntsig txog kev tswj lub cev.
Kev Cuam Tshuam Rau Kev Ua Haujlwm Spontaneous Locomotor: Ntawm koob tshuaj ntawm 30 mg / kg, lycorine tau pom tias ua rau kev ua haujlwm spontaneous locomotor tsis zoo hauv nas, raws li qhia los ntawm kev txo qis hauv kev coj cwj pwm thiab kev nce ntxiv ntawm kev tsis txav chaw.
Kev coj cwj pwm thiab kev noj qab haus huv dav dav: Ib koob tshuaj ntawm 10 mg / kg ntawm lycorine tsis ua rau muaj kev cuam tshuam rau kev coj cwj pwm thiab kev noj qab haus huv ntawm cov nas, qhia tias qhov no yuav yog qhov koob tshuaj zoo tshaj plaws rau kev ntsuam xyuas kev kho mob yav tom ntej.
Tsis Muaj Tej Yam Tsis Zoo Rau Qhov Hnyav Ntawm Lub Cev Los Yog Kev Noj Qab Haus Huv: Kev siv lycorine thiab lycorine hydrochloride tsis ua rau muaj tej yam tsis zoo rau qhov hnyav ntawm lub cev los yog kev noj qab haus huv tag nrho hauv cov nas uas muaj qog nqaij hlav.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias txawm hais tias lycorine tau pom tias muaj peev xwm hauv kev tshawb nrhiav ua ntej, kev ntsuam xyuas kev lom mus sij hawm ntev tseem tsis tau muaj. Kev tshawb fawb ntxiv yog qhov yuav tsum tau ua kom nkag siab tag nrho nws cov ntaub ntawv kev nyab xeeb, tshwj xeeb tshaj yog rau kev siv mus sij hawm ntev thiab hauv cov chaw kho mob. Cov kev mob tshwm sim thiab kev nyab xeeb ntawm lycorine yuav txawv nyob ntawm qhov ntau npaum li cas, txoj kev siv, thiab tus cwj pwm ntawm tus neeg mob. Ib txwm sab laj nrog tus kws kho mob ua ntej xav txog kev siv cov tshuaj ntxiv lossis kev kho mob tshiab.
